Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.

@article{Bignell2006SequenceAO,
  title={Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.},
  author={Graham R. Bignell and Raffaella Smith and C. Travis Hunter and P. Stephens and Helen Davies and Chris Greenman and J. W. Teague and Adam P. Butler and Sarah J Edkins and Claire E. Stevens and Sarah O'meara and Adrian G. Parker and Tim Avis and Syd Barthorpe and Lisa Brackenbury and Gemma Buck and Jody Clements and Jennifer Cole and Ed M. Dicks and Ken Edwards and Simon Forbes and Matthew John Gorton and Kristian A. Gray and Kelly A. Halliday and Rachel Harrison and Katy Hills and Jonathon Hinton and David Oldham. Jones and Vivienne Kosmidou and Ross Laman and Richard H. Lugg and Andrew Menzies and Janet Elise. Perry and Robert D. Petty and Keiran M Raine and Rebecca Shepherd and Alexandra Joanne Small and Helen M. Solomon and Yvonne Day Stephens and Calli Tofts and Jennifer Varian and Anthony M Webb and Sofie West and Sara Widaa and Andy Yates and Ad J. M. Gillis and Hans Stoop and Ruud H van Gurp and J Wolter Oosterhuis and Leendert H. J. Looijenga and P. Andrew Futreal and Richard Wooster and Michael R. Stratton},
  journal={Genes, chromosomes & cancer},
  year={2006},
  volume={45 1},
  pages={
          42-6
        }
}
The protein kinase gene family is the most frequently mutated in human cancer. Previous work has documented activating mutations in the KIT receptor tyrosine kinase in testicular germ-cell tumors (TGCT). To investigate further the potential role of mutated protein kinases in the development of TGCT and to characterize the prevalence and patterns of point mutations in these tumors, we have sequenced the coding exons and splice junctions of the annotated protein kinase family of 518 genes in a… CONTINUE READING
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