Sequence analysis of the hepatitis B virus pre-C region in hepatocellular carcinoma [HCC] and nontumoral liver tissues from HCC patients.

@article{Manzin1992SequenceAO,
  title={Sequence analysis of the hepatitis B virus pre-C region in hepatocellular carcinoma [HCC] and nontumoral liver tissues from HCC patients.},
  author={Aldo Manzin and Stefano Menzo and Patrizia Bagnarelli and Pietro Emanuele Varaldo and Italo Bearzi and G. Carloni and Francis Galibert and Massimo Clementi},
  journal={Virology},
  year={1992},
  volume={188 2},
  pages={890-5}
}
We investigated whether replication-competent pre-C/C defective mutants of hepatitis B virus (HBV) are detectable in primary human hepatocellular carcinoma (HCC) tissues from patients of a geographic area endemic for such mutants. DNAs extracted from formalin-fixed paraffin-embedded HCC samples were checked for the presence of specific HBV DNA sequences… CONTINUE READING