Sequence analysis of the four plasmid genes required to produce the circular peptide antibiotic microcin J25.

@article{Solbiati1999SequenceAO,
  title={Sequence analysis of the four plasmid genes required to produce the circular peptide antibiotic microcin J25.},
  author={Jos{\'e} O. Solbiati and Mirella Ciaccio and Ricardo N. Far{\'i}as and Jos{\'e} Eduardo G{\'o}nzalez-Pastor and Felipe Moreno and Ra{\'u}l Armando Salom{\'o}n},
  journal={Journal of bacteriology},
  year={1999},
  volume={181 8},
  pages={2659-62}
}
A 4.8-kb plasmid region carrying the four genes mcjABCD necessary for production of and immunity to the cyclic peptide antibiotic microcin J25 (MccJ25) has been sequenced. mcjA encodes the primary structure of MccJ25 as a precursor endowed with an N-terminal extension of 37 amino acids. The products of mcjB and mcjC are thought to be involved in microcin maturation, which implies cleavage of McjA and head-tail linkage of the 21-residue pro-MccJ25. The predicted McjD polypeptide, which is highly… CONTINUE READING