Sequence analysis of an HIV-1 isolate which displays unusually high-level AZT resistance in vitro.

Abstract

Multiple mutations in the reverse transcriptase (RT) gene were observed in a drug-resistant isolate of human immunodeficiency virus type 1 (HIV1) from an individual having prolonged (greater than 2 years) zidovudine (AZT) therapy. The virus replicated in PBMC's in the presence of very high concentrations of AZT (125 microM). Drug-sensitive strains were… (More)

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@article{Muckenthaler1992SequenceAO, title={Sequence analysis of an HIV-1 isolate which displays unusually high-level AZT resistance in vitro.}, author={Martina U. Muckenthaler and Nikolas Gunkel and P Levantis and Kim Broadhurst and Beng Tin Goh and Bryanne N. Colvin and Greta E Forster and George Gee Jackson and John S. Oxford}, journal={Journal of medical virology}, year={1992}, volume={36 2}, pages={79-83} }