Sequence analysis of RNA species synthesized by Q beta replicase without template.

@article{Biebricher1993SequenceAO,
  title={Sequence analysis of RNA species synthesized by Q beta replicase without template.},
  author={Christof K. Biebricher and R{\"u}diger Luce},
  journal={Biochemistry},
  year={1993},
  volume={32 18},
  pages={
          4848-54
        }
}
Q beta replicase amplifies certain short-chained RNA templates autocatalytically with high efficiency. In the absence of extraneously added template, synthesis of new RNA species by Q beta replicase is observed under conditions of high enzyme and substrate concentrations and after long lag times. Even under identical conditions, different RNA species are produced in different experiments. The sequences of several independent template-free products have been determined by cloning their cDNAs… CONTINUE READING
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