Sequence analysis of EBV immediate-early gene BZLF1 and BRLF1 in lymphomas.

@article{Yang2014SequenceAO,
  title={Sequence analysis of EBV immediate-early gene BZLF1 and BRLF1 in lymphomas.},
  author={Ying Yang and Yuping Jia and Yun Wang and Xiaofeng Wang and Zhifu Sun and Bing Luo},
  journal={Journal of medical virology},
  year={2014},
  volume={86 10},
  pages={
          1788-95
        }
}
The immediate-early (IE) genes, BZLF1 and BRLF1, play an important role in switching Epstein-Barr virus from the latent to the lytic state. The functions of the two IE genes and their respective proteins: ZEBRA and Rta have been well studied, but little is known about their DNA coding sequence variations and disease association. In order to investigate the sequence variation patterns and elucidate their association with lymphomas, BZLF1 and BRLF1 were analyzed in 26 and 33 lymphomas using PCR… CONTINUE READING
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