Sequence analysis and transcriptional regulation of the Escherichia coli grpE gene, encoding a heat shock protein.

@article{Lipiska1988SequenceAA,
  title={Sequence analysis and transcriptional regulation of the Escherichia coli grpE gene, encoding a heat shock protein.},
  author={Barbara Lipińska and Jonathan King and Debbie Ang and Costa P. Georgopoulos},
  journal={Nucleic acids research},
  year={1988},
  volume={16 15},
  pages={7545-62}
}
We have sequenced the Escherichia coli grpE gene and shown that it encodes a 197-amino acid residue protein of 21,668-Mr. The predicted N-terminal amino acid sequence, as well as the overall amino acid composition agree well with that of the purified protein. From Northern analysis, we have shown that transcription of the grpE gene is under heat shock regulation, i.e., there is a rapid and transient increase in the rate of synthesis of grpE mRNA upon a shift-up in temperature. Forty-six bases… CONTINUE READING
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