Sequence analysis and expression of the P450 aromatase and estrogen receptor genes in the Xenopus ovary.

@article{Miyashita2000SequenceAA,
  title={Sequence analysis and expression of the P450 aromatase and estrogen receptor genes in the Xenopus ovary.},
  author={Kazutoshi Miyashita and Nobuyoshi Shimizu and S Osanai and Shohei Miyata},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2000},
  volume={75 2-3},
  pages={101-7}
}
Recent studies point to a key role for the estrogen synthesizing enzyme P450 aromatase (P450 arom) in ovary determination in fish, birds and reptiles. It is unclear whether estrogen synthesis is important in sex determination of Xenopus gonad. To determine whether the aromatase gene is transcribed in the gonads of Xenopus tadpoles during the sex determination, we cloned a P450 arom cDNA and examined the level of P450 arom and estrogen receptor (ER) gene expression in association with estrogen… CONTINUE READING