Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1.

@article{Dixon1997SequenceAI,
  title={Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1.},
  author={Jill Dixon and Karine Hovanes and Rita Shiang and Michael James Dixon},
  journal={Human molecular genetics},
  year={1997},
  volume={6 5},
  pages={727-37}
}
The gene mutated in Treacher Collins syndrome, an autosomal dominant disorder of facial development, has recently been cloned. While the function of the predicted protein, Treacle, is unknown, it has been shown to share a number of features with the highly phosphorylated nucleolar phosphoproteins, which play a role in nucleolar-cytoplasmic transport. In the current study, the murine homologue of the Treacher Collins syndrome gene has been isolated and shown to encode a low complexity, serine… CONTINUE READING

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Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences

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