Sequence analysis, chromosomal location, and developmental expression of the mouse preproendothelin-1 gene.

@article{Maemura1996SequenceAC,
  title={Sequence analysis, chromosomal location, and developmental expression of the mouse preproendothelin-1 gene.},
  author={Koji Maemura and Hiroki Kurihara and Yasuyuki Kurihara and Hisanobu Oda and Tomoo Ishikawa and Neal G. Copeland and Debra J. Gilbert and Nancy A. Jenkins and Yoshio Yazaki},
  journal={Genomics},
  year={1996},
  volume={31 2},
  pages={177-84}
}
Recent studies have designated endothelins (ETs) as morphogenetic factors in embryonic development. In the present study, we cloned and characterized the mouse preproendothelin-1 (preproET-1) gene (Edn1) and examined its expression in reference to development. Edn1 comprises five exons, and the open reading frame encodes the 202-amino-acid preproET-1. The sequences and structural organization of Edn1 are highly homologous to those of other species, especially in the terminal 200-bp sequence of… CONTINUE READING
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