Sequence alterations of insulin-like growth factor binding protein 3 in neoplastic and normal gastrointestinal tissues.

@article{Zou1998SequenceAO,
  title={Sequence alterations of insulin-like growth factor binding protein 3 in neoplastic and normal gastrointestinal tissues.},
  author={Tongtong Zou and A Steven Fleisher and Dehe Kong and Jiang Yin and Rhonda F Souza and Suna Wang and Kara N. Smolinski and John M. Abraham and Stephen J. Meltzer},
  journal={Cancer research},
  year={1998},
  volume={58 21},
  pages={4802-4}
}
Insulin-like growth factor binding protein 3 (IGFBP-3) is an important regulator of normal and malignant cell growth. It modulates the mitogenic effects of insulin-like growth factors (IGFs) by inhibiting growth through mechanisms both dependent on and independent of IGF binding. IGF-I and IGF-II levels are regulated by binding to the IGF-II receptor, which is inactivated by mutation in human gastrointestinal (GI) tumors. We have previously demonstrated elevated IGF-II ligand expression in IGF… CONTINUE READING

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