Sequence Variation in the tRNA Genes of Human Mitochondrial DNA

@article{Vilmi2003SequenceVI,
  title={Sequence Variation in the tRNA Genes of Human Mitochondrial DNA},
  author={Tiina Vilmi and Jukka S Moilanen and Saara M Finnil{\"a} and Kari Majamaa},
  journal={Journal of Molecular Evolution},
  year={2003},
  volume={60},
  pages={587-597}
}
Recent analyses have shown that nonsynonymous variation in human mitochondrial DNA (mtDNA) contains nonneutral variants, suggesting the presence of mildly deleterious mutations. Many of the disease-causing mutations in mtDNA occur in the genes encoding the tRNAs. Nucleotide sequence variation in these genes has not been studied in human populations, nor have the structural consequences of nucleotide substitutions in tRNA molecules been examined. We therefore determined the nucleotide sequences… CONTINUE READING