Sequence Variation in the Tbx4 Gene in Marine Mammals

  title={Sequence Variation in the Tbx4 Gene in Marine Mammals},
  author={Kaori Onbe and S. Nishida and E. Sone and N. Kanda and M. Goto and L. Pastene and S. Tanabe and H. Koike},
  booktitle={Zoological science},
Abstract The amino-acid sequences of the T-domain region of the Tbx4 gene, which is required for hindlimb development, are 100% identical in humans and mice. Cetaceans have lost most of their hindlimb structure, although hindlimb buds are present in very early cetacean embryos. To examine whether the Tbx4 gene has the same function in cetaceans as in other mammals, we analyzed Tbx4 sequences from cetaceans, dugong, artiodactyls and marine carnivores. A total of 39 primers were designed using… Expand


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