Sequence Variation in the Tbx4 Gene in Marine Mammals

@inproceedings{Onbe2007SequenceVI,
  title={Sequence Variation in the Tbx4 Gene in Marine Mammals},
  author={Kaori Onbe and Shin Nishida and Emi Sone and Naohisa Kanda and Mutsuo Goto and Luis A. Pastene and Shinsuke Tanabe and Hiroko Koike},
  booktitle={Zoological science},
  year={2007}
}
Abstract The amino-acid sequences of the T-domain region of the Tbx4 gene, which is required for hindlimb development, are 100% identical in humans and mice. Cetaceans have lost most of their hindlimb structure, although hindlimb buds are present in very early cetacean embryos. To examine whether the Tbx4 gene has the same function in cetaceans as in other mammals, we analyzed Tbx4 sequences from cetaceans, dugong, artiodactyls and marine carnivores. A total of 39 primers were designed using… 

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