Sequence-Specific Peptide Synthesis by an Artificial Small-Molecule Machine

@article{Lewandowski2013SequenceSpecificPS,
  title={Sequence-Specific Peptide Synthesis by an Artificial Small-Molecule Machine},
  author={Bartosz Lewandowski and Guillaume De Bo and John W Ward and Marcus Papmeyer and Sonja Kuschel and Mar{\'i}a Jos{\'e} Aldegunde and P. M. E. Gramlich and D Heckmann and Stephen M. Goldup and Daniel M. D'Souza and and Errol Fernandes and David A. Leigh},
  journal={Science},
  year={2013},
  volume={339},
  pages={189 - 193}
}
Ribosomal Rotaxane? The ribosome is an extraordinarily sophisticated molecular machine, assembling amino acids into proteins based on the precise sequence dictated by messenger RNA. Lewandowski et al. (p. 189) have now taken a step toward the preparation of a stripped-down synthetic ribosome analog. Their machine comprises a rotaxane—a ring threaded on a rod—in which the ring bears a pendant thiol that can pluck amino acids off the rod; the terminal nitrogen then wraps around to form a peptide… Expand
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