Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes

@inproceedings{Slyke2015SequenceSpecificFA,
  title={Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes},
  author={Greta Van Slyke and Jamie J Arnold and Alex J. Lugo and Sara B. Griesemer and Ibrahim M Moustafa and Laura D Kramer and Craig E Cameron and Alexander T. Ciota and Scott C Weaver},
  booktitle={PLoS pathogens},
  year={2015}
}
High rates of error-prone replication result in the rapid accumulation of genetic diversity of RNA viruses. Recent studies suggest that mutation rates are selected for optimal viral fitness and that modest variations in replicase fidelity may be associated with viral attenuation. Arthropod-borne viruses (arboviruses) are unique in their requirement for host cycling and may necessitate substantial genetic and phenotypic plasticity. In order to more thoroughly investigate the correlates… CONTINUE READING
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