Sequence Database Compression for Peptide Identification from Tandem Mass Spectra

  title={Sequence Database Compression for Peptide Identification from Tandem Mass Spectra},
  author={Nathan Edwards and Ross Lippert},
The identification of peptides from tandem mass spectra is an important part of many high-throughput proteomics pipelines. In the high-throughput setting, the spectra are typically identified using software that matches tandem mass spectra with putative peptides from amino-acid sequence databases. The effectiveness of these search engines depends heavily on the completeness of the amino-acid sequence database used, but suitably complete amino-acid sequence databases are large, and the sequence… CONTINUE READING

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