Sequence-Controlled Polymers

  title={Sequence-Controlled Polymers},
  author={Jean‐François Lutz and Makoto Ouchi and David R. Liu and Mitsuo Sawamoto},
Background During the last few decades, progress has been made in manipulating the architecture of synthetic polymer materials. However, the primary structure—that is, the sequential arrangement of monomer units in a polymer chain—is generally poorly controlled in synthetic macromolecules. Common synthetic polymers are usually homopolymers, made of the same monomer unit, or copolymers with simple chain microstructures, such as random or block copolymers. These polymers are used in many areas… 

Alternating Copolymers Based on Amino Acids and Peptides

This book chapter aims to focus on recent developments of amino acid and peptide-based alternating architectures, their interesting properties and applications as bioinspired nanomaterials, in inclusion chemistry, catalysis, sensing, tissue engineering, molecular electronics, molecular separation technology, and so on.

Sequence-controlled supramolecular terpolymerization directed by specific molecular recognitions

The development of sequence-controlled supramolecular terpolymerization via a self-sorting behavior among three sets of monomers possessing mismatched host–guest pairs is reported.

Sequence-controlled polymers via reversible-deactivation radical polymerization

The development of reversible-deactivation radical polymerization (RDRP) has made a great contribution not only in controlling the molecular weight and terminal structures but also in the precise

Sequence Programmable Peptoid Polymers for Diverse Materials Applications

Polymer sequence programmability is required for the diverse structures and complex properties that are achieved by native biological polymers, but efforts towards controlling the sequence of

Defining the Field of Sequence-Controlled Polymers.

  • J. Lutz
  • Biology
    Macromolecular rapid communications
  • 2017
All synthetic approaches that have been reported for the synthesis of SCPs are discussed and categorized, and the characterization tools, properties, and potential applications of these new polymers are described herein.

Sequence-controlled methacrylic multiblock copolymers via sulfur-free RAFT emulsion polymerization

A rapid and quantitative synthesis of sequence-controlled multiblock polymers in discrete stable nanoscale compartments via an emulsion polymerization approach in which a vinyl-terminated macromolecule is used as an efficient chain-transfer agent is reported.

Cyclopolymerizations: Synthetic Tools for the Precision Synthesis of Macromolecular Architectures.

This review gives an account of recent developments related to the use of monomers possessing two functionalities suitable for polymerization in cyclopolymerization processes, in order to form linear, soluble macromolecules.

Clickable Nucleic Acids: Sequence-Controlled Periodic Copolymer/Oligomer Synthesis by Orthogonal Thiol-X Reactions.

Two click chemistry reactions were now combined to form nucleobase-containing sequence-controlled polymers in simple polymerization reactions, used for organogel formation where complementary CNA-based polymers form reversible crosslinks.

Synthesis of Monodisperse Sequence‐Defined Polymers Using Protecting‐Group‐Free Iterative Strategies

The synthesis of “precision” polymers with fi nely controlled molecular structures is an important new development in synthetic polymer chemistry. This trend is the logical outcome of the continuing



Controlled folding of synthetic polymer chains through the formation of positionable covalent bridges

Reactive alkyne groups have now been placed at specific locations in linear polystyrene chains, enabling those to be folded into predetermined shapes through intramolecular covalent bonding.

Sequence control in polymer synthesis.

Both biological and synthetic mechanisms for controlling sequences in polymerization processes are critically discussed herein and may serve as a source of inspiration for the development of new generations of synthetic macromolecules.

Sequence-regulated radical polymerization with a metal-templated monomer: repetitive ABA sequence by double cyclopolymerization.

The sequence ofpolymers is recognized as the next structural factor that can be controlled precisely in artificial polymerizations to express advanced functions of polymers as observed in nature.

Ultra-precise insertion of functional monomers in chain-growth polymerizations

This work describes a specific range of experimental conditions that allows ultra-precise incorporation of a single N-substituted maleimide unit in a polystyrene chain and shows that it is possible to restore these particular kinetic conditions multiple times during a single polymerization by using successive feeds of donor and acceptor comonomers.

Cycloaddition-promoted self-assembly of a polymer into well-defined beta sheets and hierarchical nanofibrils.

A new strategy of constructing covalent synthetic polymers that fold into well-defined β-sheets and further assemble into hierarchical nanofibrils is described.

Architecturally Complex Polymers with Controlled Heterogeneity

Advanced materials used in health and beauty products, optoelectronic and microelectronic materials, and structural applications have been developed by combining all of these elements—composition, topology, and functionality—into one material, and to do so in ways that reduce the complexity and cost of synthesis.

DNA block copolymers: functional materials for nanoscience and biomedicine.

This Account discusses selected examples of recent developments in the synthesis, structure manipulation and applications of DNA block copolymers, and presents achievements in synthesis of DBCs and their amplification based on molecular biology techniques.

Precision Polymers: Monodisperse, Monomer‐Sequence‐Defined Segments to Target Future Demands of Polymers in Medicine

Due to the absence of chemical and molecular‐weight distributions in these multifunctional segments, exact correlation of the monomer sequence and (bio)properties is attainable, demonstrated by the design of carrier systems that exhibit fine‐tuned interactions with plasmid DNA.

Single-chain technology using discrete synthetic macromolecules.

These recent advances in macromolecular science are described in detail and the possible emergence of technologies based on single-chain devices are emphasized.