Sequence Characterization of Teleost Fish Melanocortin Receptors

@article{Logan2003SequenceCO,
  title={Sequence Characterization of Teleost Fish Melanocortin Receptors},
  author={Darren W. Logan and Robert J. Bryson-Richardson and Martin S. Taylor and Peter David Currie and Ian J. Jackson},
  journal={Annals of the New York Academy of Sciences},
  year={2003},
  volume={994}
}
Abstract: Zebrafish are an excellent model system for studying the function of melanocortins in developmental and physiological processes, not least because there are a considerable number of mutant lines in which pigment patterns are affected. The behavior of fish melanophores is influenced by α‐melanocyte‐stimulating hormone (α‐MSH) and melanin‐concentrating hormone (MCH). We have used a rapid assay for α‐MSH and MCH function using melanophores present on single zebrafish scales. By in silico… 

Regulation of pigmentation in zebrafish melanophores.

The zebrafish is proposed to be an experimental model for studying both physiological colour change and the molecular basis of pigment translocation, and the importance of cyclic adenosine monophosphate (cAMP) as a mediator of pigment translation is confirmed.

Characterization of two melanin‐concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system

It is demonstrated that zebrafish MCH2 is the putative structural and functional ortholog of mammalian MCH and help elucidate the nature of MCH evolution among vertebrates.

Molecular characterization, tissue-specific expression, and regulation of melanocortin 2 receptor in rainbow trout.

Results demonstrate that ACTH regulation of MC2R is highly conserved in vertebrates, whereas the tissue-specific distribution of this receptor transcript level leads us to propose a role for ACTH signaling in the stressor-mediated suppression of sex steroid levels in fish.

New insights into melanosome transport in vertebrate pigment cells.

Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin

This review focuses on the ligands for neural MCRs, including classical ligands (MSH and agouti-related peptide), nonclassical liganded (lipocalin 2, β-defensin, small molecules, and pharmacoperones), and clinically approved ligand (ACTH, setmelanotide, bremelAnotide, and several repurposed drugs).

Molecular cloning, tissue distribution, and pharmacological characterization of blunt snout bream (Megalobrama amblycephala) melanocortin-5 receptor

The molecular cloning, tissue expression, and pharmacological characterization of Megalobrama amblycephala MC5R, as well as the effect of catching stress on its expression, suggested that MamMC5R might play a role in stress response in M. amblyCEphala.

References

SHOWING 1-10 OF 20 REFERENCES

One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology

The studies, which represent the first characterization of MC receptors in a nonamniote species, indicate that the MC receptor subtypes arose very early in vertebrate evolution.

Homologous pigmentation mutations in human, mouse and other model organisms.

This review tabulate the available data on all pigmentation genes cloned from mouse or human, and focuses on three particular systems, including LYST and HPS/ep, which shows the relationship between melanosomes and lysosomes.

Melanocortin 1 receptor variation in the domestic dog

The results indicate that the e allele is caused by a common Mc1r loss-of-function mutation that either reoccurred or was subject to gene conversion during recent evolutionary history, and suggest that the allelic and locus relationships for dog coat color genes may be more analogous to those found in other mammals than previously thought.

Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio.

Evidence is provided that these genes are required for three different aspects of xanthophore development: pigment cell formation and migration (pfeffer and salz); pigment synthesis (edison, yobo, yocca and brie); and pigment translocation (esrom, tilsit and tofu).

Functional variation of MC1R alleles from red-haired individuals.

Comparison of the phenotypes of alphaMSH-deficient mice and humans in conjunction with this data suggests that red hair may not be the null phenotype of MC1R, suggesting agouti protein may not play a role in human pigmentary variation.

Conformation of the Core Sequence in Melanocortin Peptides Directs Selectivity for the Melanocortin MC3 and MC4 Receptors*

This study provides a general concept for peptide receptor selectivity, in which the major determinant for a selective receptor interaction is the conformational presentation of the core sequence in related peptides to the receptor-binding pocket.

Zebrafish pigmentation mutations and the processes of neural crest development.

Comparison of their phenotypes permits classification of these mutations according to the types of defects they cause, and these suggest which process of neural crest development is probably affected, as part of a large-scale mutagenesis screen for embryonic/early larval mutations.