Sequence-Based Prediction of Type III Secreted Proteins

  title={Sequence-Based Prediction of Type III Secreted Proteins},
  author={Roland Arnold and Stefan Brandmaier and Frederick Kleine and Patrick Tischler and Eva Heinz and Sebastian Behrens and Antti Niinikoski and Hans-Werner Mewes and Matthias Horn and Thomas Rattei},
  journal={PLoS Pathogens},
  pages={1 - 10}
The type III secretion system (TTSS) is a key mechanism for host cell interaction used by a variety of bacterial pathogens and symbionts of plants and animals including humans. The TTSS represents a molecular syringe with which the bacteria deliver effector proteins directly into the host cell cytosol. Despite the importance of the TTSS for bacterial pathogenesis, recognition and targeting of type III secreted proteins has up until now been poorly understood. Several hypotheses are discussed… CONTINUE READING
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