Sequence Analysis of Measles Virus Nucleocapsid Transcripts in Patients with Paget's Disease

@article{Friedrichs2002SequenceAO,
  title={Sequence Analysis of Measles Virus Nucleocapsid Transcripts in Patients with Paget's Disease},
  author={William E. Friedrichs and Sakamuri V Reddy and Jan M Bruder and Tim Cundy and Jillian Cornish and Frederick R. Singer and G. David Roodman},
  journal={Journal of Bone and Mineral Research},
  year={2002},
  volume={17}
}
It has been debated for almost 30 years whether Paget's disease of bone results from paramyxoviral infection of osteoclasts (OCs). Paramyxoviral‐like nuclear inclusions are found in OCs from patients with Paget's disease, and measles virus (MV) or canine distemper virus (CDV) messenger RNA (mRNA) transcripts have been detected by in situ hybridization in bone cells from pagetic lesions. Furthermore, immunocytochemical studies have shown the presence of several paramyxoviral species in OCs from… Expand
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References

SHOWING 1-10 OF 32 REFERENCES
Failure to detect paramyxovirus sequences in paget's disease of bone using the polymerase chain reaction
TLDR
This study fails to support the hypothesis that active infection with one of these or a related paramyxovirus is involved in the pathogenesis of Paget's disease. Expand
Absence of paramyxovirus RNA in cultures of pagetic bone cells and in pagetic bon
TLDR
The work presented here further questions the role of measles and CDV in the abnormal remodeling observed in Paget's disease. Expand
Measles virus RNA detected in Paget's disease bone tissue by in situ hybridization.
TLDR
In five patients with the disease, measles virus RNA sequences were detected not only in 80 to 90% of the multinucleated osteoclasts where there is morphological and immunocytological evidence of measles virus activity but also in 30 to 40% of mononucleated bone cells, mainly osteoblasts, osteocytes, fibroblasts and lympho-monocytes. Expand
Absence of measles virus and canine distemper virus transcripts in long-term bone marrow cultures from patients with Paget's disease of bone.
TLDR
The results of this study do not support a role for MV or CDV in the pathogenesis of Paget's disease of bone. Expand
Paramyxoviruses and Paget's disease
TLDR
It is shown that CDV can infect a human host and may be an aetiological agent of Paget's disease of bone. Expand
Detection of measles virus nucleocapsid transcripts in circulating blood cells from patients with paget disease
TLDR
It is found that osteoclast precursors, as well as peripheral blood mononuclear cells, express MV transcripts in 9 of 13 patients, and this data suggest that the pagetic marrow microenvironment plays a critical role in maintaining the highly localized nature of the lesions in Paget disease. Expand
Bone marrow mononuclear cells from patients with Paget's disease contain measles virus nucleocapsid messenger ribonucleic acid that has mutations in a specific region of the sequence.
TLDR
These data show that unlike those from normal subjects, marrow mononuclear cells from Paget's patients express MV nucleocapsid messenger ribonucleic acid, and suggest a persistent MV infection in Pagetic osteoclast precursors, and further suggest that osteoclasts are infected by fusion with infected precursor. Expand
In Situ Analysis of Paget's Disease of Bone for Measles‐Specific PCR‐Amplified cDNA
TLDR
Data suggest that infection by the measles virus is not associated with Paget's disease of bone, and nucleic acid sequences homologous to measles virus are searched for using the recently described reverse transcriptase (RT) polymerase chain reaction (PCR) in situ hybridization (ISH) technique. Expand
RANKing the importance of measles virus in Paget's disease.
  • F. Ross
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2000
TLDR
Paget’s disease, a common, multifocal skeletal disorder, provides a paradigm of bone remodeling gone awry, and the presence of viral mRNA in mesenchymal cells in bone raises the possibility that nonhematopoietic cells also play a role in the disease. Expand
Canine distemper virus transcripts sequenced from pagetic bone.
TLDR
In Paget's disease, canine distemper and possible other paramyxoviruses reside in bone cells and that the persistent nature of the virus may be due to mutations in the viral genome. Expand
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