Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study.

@article{Hawkins2006SequenceHA,
  title={Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study.},
  author={Gregory A Hawkins and Kelan Tantisira and Deborah A. Meyers and Elizabeth J. Ampleford and W. C. Moore and Barbara J. Klanderman and Stephen B. Liggett and Stephen P. Peters and Scott T. Weiss and Eugene Bleecker},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={174 10},
  pages={1101-9}
}
RATIONALE The comprehensive evaluation of gene variation, haplotype structure, and linkage disequilibrium is important in understanding the function of beta2-adrenergic receptor gene (ADRbeta2) on disease susceptibility, pulmonary function, and therapeutic responses in different ethnic groups with asthma. OBJECTIVES To identify ADRbeta2 polymorphisms and haplotype structure in white and African American subjects and to test for genotype and haplotype association with asthma phenotypes… CONTINUE READING