Septo-hippocampal connections and the hippocampal theta rhythm

  title={Septo-hippocampal connections and the hippocampal theta rhythm},
  author={J. Nicholas P. Rawlins and Joram Feldon and Jeffrey A. Gray},
  journal={Experimental Brain Research},
SummaryRecordings were made of spontaneous hippocampal theta activity in free-moving rats, before and after a variety of lesions. Three recording sites were used to monitor activity in the dorsal hippocampus, the ventral hippocampus, or close to the site of the hippocampal flexure. Electrolytic lesions were made in the medial septal area or the dorso-lateral septal area; surgical transections were made of the fimbria or dorso-medial area of the fornix. Following lesions restricted to the medial… 

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    Journal of comparative and physiological psychology
  • 1976
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    Behavioral biology
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