Septins promote stress fiber–mediated maturation of focal adhesions and renal epithelial motility

@inproceedings{Dolat2014SeptinsPS,
  title={Septins promote stress fiber–mediated maturation of focal adhesions and renal epithelial motility},
  author={Lee Dolat and John L. Hunyara and Jonathan R. Bowen and Eva Pauline Karasmanis and Maha Elgawly and Vitold E Galkin and Elias T Spiliotis},
  booktitle={The Journal of cell biology},
  year={2014}
}
Organogenesis and tumor metastasis involve the transformation of epithelia to highly motile mesenchymal-like cells. Septins are filamentous G proteins, which are overexpressed in metastatic carcinomas, but their functions in epithelial motility are unknown. Here, we show that a novel network of septin filaments underlies the organization of the transverse arc and radial (dorsal) stress fibers at the leading lamella of migrating renal epithelia. Surprisingly, septin depletion resulted in smaller… CONTINUE READING

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