Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells

Abstract

Microtentacles are mostly microtubule-based cell protrusions that are formed by detached tumor cells. Here, we report that the formation of tumor cell microtentacles depends on the presence and dynamics of guanine nucleotide-binding proteins of the septin family, which are part of the cytoskeleton. In matrix-attached breast, lung, prostate and pancreas… (More)
DOI: 10.18632/oncotarget.20805

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