Pangolin genomes and the evolution of mammalian scales and immunity.
- Biology, MedicineGenome research
It is proposed that scale development was an innovation that provided protection against injuries or stress and reduced pangolin vulnerability to infection, and perhaps a new natural IFNE-deficient animal model for studying mammalian immunity.
SHOWING 1-3 OF 3 REFERENCES
Autophagy and the cytoskeleton
- Biology, MedicineAutophagy
It is revealed that infected host cells can prevent actin-based motility of Shigella by compartmentalizing bacteria inside ‘septin cages,’ revealing a novel mechanism of host defense that restricts dissemination.
Entrapment of intracytosolic bacteria by septin cage-like structures.
- Biology, MedicineCell host & microbe
It is reported that septin assemblies are recruited to different bacteria that polymerize actin, and it is observed that intracytosolic Shigella either become compartmentalized in septin cage-like structures or form actin tails.
The pathobiology of the septin gene family
- Biology, MedicineThe Journal of pathology
It is posited that septins can act as regulatable scaffolds where the stoichiometry of septin associations, modifications, GTP status, and the interactions with other proteins allow the regulation of key cellular processes including polarity determination.