Failure of microcirculation in septic shock is due to the generalized release of catecholamins following a fall in cardiac output by the activity of bacterial toxin. The failure of the microcirculation can be defined as 1. a failure of the distribution of the tissue perfusion, and 2. a decrease of capillary flow due to obstructed inflow, reduced capillary flow passage and obstructed outflow. Bloodviscosity increases because of fluid sequestration, aggregation of rbc's and decrease in velocity of the blood flow. All this results in a dispariaty of oxygen consumption and availability to the tissue. The characteristics of specific organ disturbances in shock go along with the distribution of the alpha-receptors in each organ, the specific physiological function and architecture of the organ as well as previous diseases of the organ.