Septation, dephosphorylation, and the activation of sigmaF during sporulation in Bacillus subtilis.

@article{King1999SeptationDA,
  title={Septation, dephosphorylation, and the activation of sigmaF during sporulation in Bacillus subtilis.},
  author={Natalie D. King and Oliver Dreesen and P. Stragier and Kit Pogliano and Richard Losick},
  journal={Genes & development},
  year={1999},
  volume={13 9},
  pages={1156-67}
}
Cell-specific activation of transcription factor sigmaF during sporulation in Bacillus subtilis requires the formation of the polar septum and the activity of a serine phosphatase (SpoIIE) located in the septum. The SpoIIE phosphatase indirectly activates sigmaF by dephosphorylating a protein (SpoIIAA-P) in the pathway that controls the activity of the transcription factor. By use of a SpoIIE-GFP fusion protein in time-course and time-lapse experiments and by direct visualization of septa in… CONTINUE READING