Sepsis-induced muscle proteolysis is prevented by a proteasome inhibitor in vivo.

  title={Sepsis-induced muscle proteolysis is prevented by a proteasome inhibitor in vivo.},
  author={David R Fischer and G T Gang and Timothy A. Pritts and Per Olof Hasselgren},
  journal={Biochemical and biophysical research communications},
  volume={270 1},
Sepsis-induced muscle proteolysis mainly reflects ubiquitin-proteasome-dependent protein degradation. The effect of in vivo administration of a proteasome inhibitor on muscle protein breakdown during sepsis is not known. We treated rats with the proteasome inhibitor N-benzyloxycarbonyl-Ile-Glu-(O-t-butyl)-Ala-leucinal (PSI) or corresponding volume of vehicle i.p. 2 h before sham-operation or induction of sepsis by cecal ligation and puncture. The sepsis-induced increase in total and… CONTINUE READING
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