Sepsis-induced apoptosis of the thymocytes in mice.

  title={Sepsis-induced apoptosis of the thymocytes in mice.},
  author={S D Wang and Kelly J. Huang and Y S Lin and H. Y. Lei},
  journal={Journal of immunology},
  volume={152 10},
Intraperitoneal injection of Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa) induces thymic atrophy in mice. The thymus weight, cell number, and viability began to decrease at 3 h, and reached their lowest level at 72 h. The thymocyte death was associated with DNA fragmentation of approximately 200 base pairs in ladder form. The kinetic study on histopathology revealed the process of thymocyte death and thymic atrophy. Flow-cytometric analysis showed… CONTINUE READING


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