Sepsis-associated delirium: the pro and con of C5a blockade

  title={Sepsis-associated delirium: the pro and con of C5a blockade},
  author={Djillali Annane},
  journal={Critical Care},
  pages={135 - 135}
The intimate mechanisms of sepsis-induced delirium are unknown. Among the potential contributing factors, the breakdown of the blood-brain barrier is considered a key determinant of brain dysfunction. The complement activation is paramount to an appropriate activation of the central nervous system during stress. C3a and C5a have been extensively studied and may be involved in sepsis-induced delirium. Here we discuss the pro and con for inhibiting C5a to attenuate brain damage during sepsis. In… CONTINUE READING

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