Sepsis: rethinking the approach to clinical research
@article{Marshall2008SepsisRT,
title={Sepsis: rethinking the approach to clinical research},
author={J. Marshall},
journal={Journal of Leukocyte Biology},
year={2008},
volume={83}
}The clinical syndrome of sepsis encompasses a highly heterogeneous group of clinical disorders, varying with respect to the site, bacteriology, and even presence of infection and with the clinical syndrome evolving in the host. Clinical trials of strategies to modulate the host response that mediates sepsis were first initiated 25 years ago. A continuing record of disappointment has characterized subsequent work, and only a single new therapy has been licensed for clinical use. Yet, these… Expand
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References
SHOWING 1-10 OF 97 REFERENCES
Such stuff as dreams are made on: mediator-directed therapy in sepsis
- Medicine
- Nature Reviews Drug Discovery
- 2003
- 270
- PDF
Clinical trials of immunomodulatory therapies in severe sepsis and septic shock.
- Medicine
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- 2002
- 225
- PDF
Outcome measures for clinical research in sepsis: A report of the 2nd Cambridge Colloquium of the International Sepsis Forum
- Medicine
- Critical care medicine
- 2005
- 129
The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study.
- Medicine
- JAMA
- 1995
- 1,963
- Highly Influential
New strategies for clinical trials in patients with sepsis and septic shock
- Medicine
- Critical care medicine
- 2001
- 168
Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome
- Medicine
- Annals of Internal Medicine
- 1993
- 1,079
Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy.
- Medicine
- Chest
- 2003
- 228
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study.
- Medicine
- The Journal of infectious diseases
- 2004
- 271
- PDF
Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.
- Medicine
- Critical care medicine
- 1989
- 106