Sepsis: Bile acids promote inflammation in cholestasis-associated sepsis

  title={Sepsis: Bile acids promote inflammation in cholestasis-associated sepsis},
  author={H. O. Thomas},
  journal={Nature Reviews Gastroenterology &Hepatology},
sepsis is aggravated by bile acids via NLRP3 inflammasome activation, according to a new study. Patients with sepsis commonly exhibit cholestasis, driven by infection-related perturbations to bile acid transport and excretion pathways. Bile acid accumulation has been suggested to exacerbate sepsis-associated inflammation; cholestasis is an early event in sepsis, and plasma bile acid levels are strongly predictive of mortality. However, a definitive role for bile acids in potentiating sepsis has… CONTINUE READING
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