Sepsis, coagulation and anticoagulants.

  title={Sepsis, coagulation and anticoagulants.},
  author={Fl{\'a}via Ribeiro Machado and Murillo Santucci Cesar},
  journal={Endocrine, metabolic & immune disorders drug targets},
  volume={10 3},
Sepsis is one of the major health problems all over the word. Its pathophysiological mechanisms are not completely understood, but coagulation alterations are a hallmark of this syndrome. There is a clear exacerbation of coagulation and a suppression of control mechanisms of this process, including a reduction in fibrinolysis with consequent impairment of fibrin removal. The leading cause of these alterations is the proinflammatory state of those patients, characterized by high cytokine levels… CONTINUE READING