Sepiapterin treatment in atherosclerosis.

@article{Tarpey2002SepiapterinTI,
  title={Sepiapterin treatment in atherosclerosis.},
  author={Margaret M. Tarpey},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2002},
  volume={22 10},
  pages={
          1519-21
        }
}
Tetrahydrobiopterin (BH4) plays an important role in functional and metabolic cellular homeostasis, with additional effects on proliferation.,1,2⇓ immune responsiveness,3,4⇓ and neuronal activity.5–7⇓⇓ Mutations in either de novo biosynthetic or regeneration (salvage) pathways result in BH4 deficiency associated with diminished levels of seratonin and dopamine with progressive neurologic symptoms.8,9⇓ The phenotypic presentation of these synthetic mutations can be predicted in large part by the… CONTINUE READING

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