Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners.

@article{Sugio1987SeparationOT,
  title={Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners.},
  author={K. Sugio and M. Maruyama and S. Tsurufuji and P. Sharma and A. Brossi},
  journal={Life sciences},
  year={1987},
  volume={40 1},
  pages={
          35-9
        }
}
The effects of colchicine and its analogs on the carrageenin-induced footpad edema in rats were investigated. The anti-inflammatory effects of colchicine analogs were measured at 3 and 5 hr after the carrageenin injection. Colchicine, 1-demethylcolchicine and 3-demethylcolchicine markedly inhibited the carrageenin edema whereas 2-demethylcolchicine was much less active. Thiocolchicinoids, having a thiomethyl group at C-10 instead of a methoxy group, were considerably less potent. These results… Expand
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References

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Mechanism of action of colchicine
Colchicine: a common mechanism for its anti-inflammatory and anti-mitotic effects.