Separation of self from non-self in the complement system.

Abstract

The alternative complement pathway is a self-contained and independent recognition and effector pathway that evolved to protect the host from microbes. As such, it must separate self from non-self. Via low grade continuous turnover (tickover) of the pivotal C3 component, the alternative complement pathway is always on guard to defend the host. Activated C3… (More)
DOI: 10.1016/0167-5699(87)90167-8

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