Separation of origin recognition complex functions by cross-species complementation.

@article{EhrenhoferMurray1995SeparationOO,
  title={Separation of origin recognition complex functions by cross-species complementation.},
  author={Ann E Ehrenhofer-Murray and Manfred Gossen and Daniel T.S Pak and Michael R Botchan and Jasper Rine},
  journal={Science},
  year={1995},
  volume={270 5242},
  pages={1671-4}
}
Transcriptional silencing at the HMRa locus of Saccharomyces cerevisiae requires the function of the origin recognition complex (ORC), the replication initiator of yeast. Expression of a Drosophila melanogaster Orc2 complementary DNA in the yeast orc2-1 strain, which is defective for replication and silencing, complemented the silencing defect but not the replication defect; this result indicated that the replication and silencing functions of ORC were separable. The orc2-1 mutation mapped to… CONTINUE READING

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