Separation of intra- and extracellular lactate NMR signals using a lanthanide shift reagent.

Abstract

This work describes the use of [Pr-DO3A] as a shift reagent for differentiating intra- and extracellular L-lactate resonance in (1)H- and (13)C-NMR spectra. DO3A acts as heptadentate ligand towards lanthanide(III) ions, leaving two coordination vacancies for the coordination of the L-lactate ion. The exchange between free and [Pr-DO3A]-bound L-lactate is… (More)

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Cite this paper

@article{Aime2002SeparationOI, title={Separation of intra- and extracellular lactate NMR signals using a lanthanide shift reagent.}, author={Silvio Aime and Mauro Botta and Valentina Mainero and Enzo Terreno}, journal={Magnetic resonance in medicine}, year={2002}, volume={47 1}, pages={10-3} }