Separation of factors required for cleavage and polyadenylation of yeast pre-mRNA.

@article{Chen1992SeparationOF,
  title={Separation of factors required for cleavage and polyadenylation of yeast pre-mRNA.},
  author={J Chen and Claire L. Moore},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 8},
  pages={3470-81}
}
Cleavage and polyadenylation of yeast precursor RNA require at least four functionally distinct factors (cleavage factor I [CF I], CF II, polyadenylation factor I [PF I], and poly(A) polymerase [PAP]) obtained from yeast whole cell extract. Cleavage of precursor occurs upon combination of the CF I and CF II fractions. The cleavage reaction proceeds in the absence of PAP or PF I. The cleavage factors exhibit low but detectable activity without exogenous ATP but are stimulated when this cofactor… CONTINUE READING

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