Separation of bisdioxopiperazine- and vanadate resistance in topoisomerase II.

Abstract

Bisdioxopiperazines are inhibitors of topoisomerase II trapping this protein as a closed clamp on DNA with concomitant inhibition of its ATPase activity. Here, we analyse the effects of N-terminal mutations identified in bisdioxopiperazine-resistant cells on ATP hydrolysis by this enzyme. We present data consistent with bisdioxopiperazine resistance arising… (More)

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Cite this paper

@article{Sorensen2005SeparationOB, title={Separation of bisdioxopiperazine- and vanadate resistance in topoisomerase II.}, author={Tina K Sorensen and Morten Grauslund and Peter Bjerre Jensen and Maxwell Sehested and Lars Hollund Jensen}, journal={Biochemical and biophysical research communications}, year={2005}, volume={334 3}, pages={853-60} }