Separation of antipsychotic drugs (clozapine, loxapine) and their metabolites by capillary zone electrophoresis.

@article{Pucci1999SeparationOA,
  title={Separation of antipsychotic drugs (clozapine, loxapine) and their metabolites by capillary zone electrophoresis.},
  author={V. Pucci and M. Raggi and E. Kenndler},
  journal={Journal of chromatography. A},
  year={1999},
  volume={853 1-2},
  pages={
          461-8
        }
}
  • V. Pucci, M. Raggi, E. Kenndler
  • Published 1999
  • Chemistry, Medicine
  • Journal of chromatography. A
  • Two antipsychotic drugs (clozapine and loxapine) and six metabolites, N-demethylclozapine, clozapine N-oxide, N-demethylloxapine (amoxapine), 7-hydroxyloxapine, 8-hydroxyloxapine, 8-hydroxyamoxapine, were separated by capillary zone electrophoresis. Variation of pH and ionic strength of the acidic phosphate buffer (pH below 4) did not enable the separation of loxapine and one of its metabolites. Resolution of the single parent drugs and their metabolites was possible in background electrolytes… CONTINUE READING
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