Separation of A- versus C-nociceptive inputs into spinal-brainstem circuits.

@article{Parry2008SeparationOA,
  title={Separation of A- versus C-nociceptive inputs into spinal-brainstem circuits.},
  author={Dilys M. Parry and F M Macmillan and Stella Koutsikou and Simon McMullan and Bridget M Lumb},
  journal={Neuroscience},
  year={2008},
  volume={152 4},
  pages={1076-85}
}
This study was designed to determine the organization of nociceptive inputs with different behavioral significance into spinal-brainstem circuits in the rat. Induction of Fos protein was used to localize spinal dorsal horn and hypothalamic neurons activated by noxious heating of the hind paw dorsum at rates known to preferentially activate C- or A-heat nociceptors. This was combined with retrograde transport of cholera toxin subunit B from the dorsolateral/lateral- (DL/L-) or the ventrolateral… CONTINUE READING
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COX-1 derived prostaglandins in the periaqueductal grey differentially control Cversus A-fibre-evoked spinal nociception

  • JL eith, AW Wilson, LF Donaldson, BM Lumb
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