Separation of 1,1'-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed

@article{Pais1997SeparationO1,
  title={Separation of 1,1'-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed},
  author={Lu{\'i}s S. Pais and J. M. Loureiro and A. Rodrigues},
  journal={Chemical Engineering Science},
  year={1997},
  volume={52},
  pages={245-257}
}
Abstract The chromatographic separation of 1,1′-bi-2-naphthol enantiomers with 3,5-dinitrobenzoyl phenylglycine bonded to silica gel stationary phases is studied. Continuous chromatography in simulated moving bed (SMB) is analyzed by modeling, simulation and operation of a SMB pilot unit Licosep 12–26 from Separex (France). A model for the prediction of the cyclic steady-state performance of the SMB is developed based on the analogy with the true moving bed (TMB). The model assumes axial… Expand
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