Separation and quantitation of oxprenolol in urine and pharmaceutical formulations by HPLC using a Chiralpak IC and UV detection

@article{Abounassif2011SeparationAQ,
  title={Separation and quantitation of oxprenolol in urine and pharmaceutical formulations by HPLC using a Chiralpak IC and UV detection},
  author={M. Abounassif and M. Hefnawy and G. Mostafa},
  journal={Monatshefte f{\"u}r Chemie - Chemical Monthly},
  year={2011},
  volume={143},
  pages={365-371}
}
  • M. Abounassif, M. Hefnawy, G. Mostafa
  • Published 2011
  • Chemistry
  • Monatshefte für Chemie - Chemical Monthly
  • A stereoselective HPLC method has been developed for the simultaneous determination of oxprenolol enantiomers in urine and pharmaceutical products. Enantiomeric resolution of oxprenolol was achieved on cellulose tris(3,5-dichlorophenylcarbamate) immobilized onto a 5 μm spherical porous silica chiral stationary phase (CSP) known as Chiralpak IC with UV detection at 273 nm. The mobile phase consisted of n-hexane:isopropanol:triethylamine 70:30:0.1 (v/v/v) at a flow rate of 1.0 cm3/min. The method… CONTINUE READING
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