Separation, identification and quantification of riboflavin and its photoproducts in blood products using high-performance liquid chromatography with fluorescence detection: a method to support pathogen reduction technology.

@article{Hardwick2004SeparationIA,
  title={Separation, identification and quantification of riboflavin and its photoproducts in blood products using high-performance liquid chromatography with fluorescence detection: a method to support pathogen reduction technology.},
  author={Christopher C Hardwick and Troy R Herivel and Shiloh C Hernandez and Patrick H Ruane and Raymond P Goodrich},
  journal={Photochemistry and photobiology},
  year={2004},
  volume={80 3},
  pages={609-15}
}
A medical device using riboflavin (RB) and light is being developed for the reduction of pathogens in platelet concentrates (MIRASOL pathogen reduction technology [PRT]). A high-performance liquid chromatography (HPLC) method for the quantification of RB and its main photoproduct, lumichrome (LC) in blood components has been developed and validated. In addition, the same method has been used to identify and quantify the presence of additional photoproducts-catabolites of RB. Levels of these… CONTINUE READING
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