Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B

Abstract

Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated.

DOI: 10.1016/j.bmcl.2014.04.090

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Cite this paper

@inproceedings{Brunet2014SeparatingTI, title={Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B}, author={Aur{\'e}lie Brunet and Tashfeen Aslam and Mark Bradley}, booktitle={Bioorganic & medicinal chemistry letters}, year={2014} }