Separating neural and vascular effects of caffeine using simultaneous EEG–FMRI: Differential effects of caffeine on cognitive and sensorimotor brain responses

@article{Diukova2012SeparatingNA,
  title={Separating neural and vascular effects of caffeine using simultaneous EEG–FMRI: Differential effects of caffeine on cognitive and sensorimotor brain responses},
  author={Ana Diukova and Jennifer Ware and Jessica E. Smith and C. John Evans and Kevin Murphy and Peter J. Rogers and Richard G. Wise},
  journal={Neuroimage},
  year={2012},
  volume={62},
  pages={239 - 249}
}
The effects of caffeine are mediated through its non-selective antagonistic effects on adenosine A(1) and A(2A) adenosine receptors resulting in increased neuronal activity but also vasoconstriction in the brain. Caffeine, therefore, can modify BOLD FMRI signal responses through both its neural and its vascular effects depending on receptor distributions in different brain regions. In this study we aim to distinguish neural and vascular influences of a single dose of caffeine in measurements of… Expand
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References

SHOWING 1-10 OF 92 REFERENCES
Dietary Caffeine Consumption Modulates fMRI Measures
TLDR
It is proposed that the outcome observed here was due to an upregulation of adenosine receptors in high users, resulting in differential contributions of the neural and vascular effects ofAdenosine in the two study populations. Expand
Effects of caffeine on the electrophysiological, cognitive and motor responses of the central nervous system.
TLDR
The qEEG seems to be the most sensitive index of the changes produced by caffeine in the central nervous system since it proved to be capable of detecting changes that were not evident in the tests of cognitive or motor performance. Expand
Prospects for quantitative fMRI: Investigating the effects of caffeine on baseline oxygen metabolism and the response to a visual stimulus in humans
TLDR
BOLD responses pre- and post-caffeine were similar despite large underlying physiological changes, indicating that the magnitude of the BOLD response alone should not be interpreted as a direct measure of underlying neurophysiological changes. Expand
Does caffeine modulate verbal working memory processes? An fMRI study
TLDR
It is suggested that caffeine modulates neuronal activity as evidenced by fMRI signal changes in a network of brain areas associated with executive and attentional functions during working memory processes. Expand
Evaluation of cognitive brain functions in caffeine users: a P3 evoked potential study.
TLDR
The results of this study indicate that caffeine leads to facilitation of information processing and motor output response of the brain. Expand
Effects of caffeine on visual evoked potential (P300) and neuromotor performance.
TLDR
The findings suggest that the positive tendency of caffeine to improve cognitive performance is probably associated with changes in the frontal cortex, a widely recognized attention area. Expand
[Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): a comparative study].
TLDR
It is suggested that caffeine and bromazepam have distinct modulatory effects on CNS functioning as well as a general measurement of "cognitive efficiency" in relation to a P300 normative database. Expand
Dose–response study of caffeine effects on cerebral functional activity with a specific focus on dependence
TLDR
It is shown that low doses of caffeine which reflect the usual human level of consumption fail to activate reward circuits in the brain and thus provide functional evidence of the very low addictive potential of caffeine. Expand
Caffeine effects on resting-state arousal
TLDR
The use of caffeine is supported as a simple tool to explore the role of arousal in both normal and atypical functioning, and this may be useful in determining the validity and importance of supposed hyper- or hypo-arousal in such syndromes as attention-deficit/hyperactivity disorder (AD/HD). Expand
Relationship between caffeine-induced changes in resting cerebral perfusion and blood oxygenation level-dependent signal.
TLDR
It is not possible to consistently enhance BOLD signal intensity magnitude by decreasing resting perfusion with caffeine, and future studies aimed at evaluating the relationship between perfusion and Bold signal intensity changes should seek a means to selectively modulate known components of the neural and vascular responses independently. Expand
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3
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5
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