Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos.

  title={Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos.},
  author={Elizabeth A V Jones and Li An Yuan and Christine Breant and Ryan J. Watts and Andrew Eichmann},
  volume={135 14},
Targeted inactivation of genes involved in murine cardiovascular development frequently leads to abnormalities in blood flow. As blood fluid dynamics play a crucial role in shaping vessel morphology, the presence of flow defects generally prohibits the precise assignment of the role of the mutated gene product in the vasculature. In this study, we show how to distinguish between genetic defects caused by targeted inactivation of the neuropilin 1 (Nrp1) receptor and hemodynamic defects occurring… CONTINUE READING


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