Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal.


One of the main impediments for obtaining DNA sequences from ancient human skeletons is the presence of contaminating modern human DNA molecules in many fossil samples and laboratory reagents. However, DNA fragments isolated from ancient specimens show a characteristic DNA damage pattern caused by miscoding lesions that differs from present day DNA… (More)
DOI: 10.1073/pnas.1318934111


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