Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor?

@article{Newton2007SeparatingTA,
  title={Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor?},
  author={Robert Newton and Neil S Holden},
  journal={Molecular Pharmacology},
  year={2007},
  volume={72},
  pages={799 - 809}
}
Glucocorticoids (corticosteroids) are highly effective in combating inflammation in the context of a variety of diseases. However, clinical utility can be compromised by the development of side effects, many of which are attributed to the ability of the glucocorticoid receptor (GR) to induce the transcription of, or transactivate, certain genes. By contrast, the anti-inflammatory effects of glucocorticoids are due largely to their ability to reduce the expression of pro-inflammatory genes. This… Expand
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